
Top 5 Best Rat Poison and Best Mouse Poison
If you’re searching for the best poison to kill rats and mice quickly and effectively, you’ve come to the right place. We’ve compiled a list of the best rat and mouse poison which will get rid of your unwelcome new pets. First, we’ll explain the most common ingredients in rat and mouse poison, which ones are the most effective, and how rodenticide kills rodents.
If you want to consider other options for getting rid of mice in or around your home before looking at the best rat and mouse poison, check out our articles on how to get rid of mice in your attic or how to catch a smart rat.
Best Mouse Poison and Best Rat Poison: The Basics
How Rodenticide Kills Mice and Rats
Most rodenticides available on the market today are types of anticoagulants. Anticoagulants prevent the production of vitamin K, which is crucial for helping blood to clot. Without this important vitamin, the rodent will start bleeding internally, which eventually leads to death.
Rodenticide can kill all types of rodents, not just mice and rats. Be careful of your placement of baits if you don’t want any squirrels, chipmunks, or other kinds of rodents to be affected.
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Types of Rodenticide
Some of the most common ingredients in rodenticide include bromadiolone, bromethalin, cholecalciferol, and diphacinone. Bromadiolone and diphacinone are the anticoagulants discussed above. However, bromethalin and cholecalciferol work to kill rodents in a different, but equally effective, way. The products that we suggested below contain these ingredients, which are proven effective at killing rats and mice quickly. The best rat and mouse poison available to non-professional typically takes a couple of days to kill the rodents, so you should not be bothered by the rodents after a maximum time frame of two weeks.
Different types of rodenticide differ in how much is required to be lethal to rodents. Products that rely on rodenticide ingredients such as warfarin, chlorophacinone, and diphacinone require multiple feeds to be lethal. Therefore, a rodent would have to return to and ingest the bait multiple times in order to be killed from it. On the other hand, single-feed baits, like their name suggests, are lethal after just one meal by rodents. However, EPA guidelines stipulate that only certain types of rodenticide are available to residential consumers (non-professionals). Even if your own DIY rodenticide use doesn’t work, don’t lose hope because professionals have access to methods that you do not.
Top 5 Best Rat and Mouse Poison
Our Rating: 4.9/5
Pros
Cons
Conclusion
This bait block comes in a rodent-attracting peanut butter flavor. This rodenticide utilizes the active ingredient of diphacinone, an anticoagulant lethal to rodents. This type of poison takes around 5 to 7 days to kill a rat or mouse. Additionally, the ingredients used in this rodenticide provide a low chance of secondary poisoning. So, if another animal eats the poisoned mouse, they have a very low chance of also experiencing the lethal effects of the poison.

Our Rating: 4.9/5
Pros
Cons
Conclusion
The trusted rodenticide uses the active ingredient of bromadiolone. As one of the best rat and mouse poison products on the market, this ingredient kills mice and rats after just one feeding. However, some sources report that groups of mice or rats are more likely to learn to avoid single-feed baits. This bait is weather-resistant, so it can be used indoors or outdoors with the correct placement. If you’re looking for a quick solution to a small rodent problem, this may be the bait for you.

Our Rating: 4.8/5
Pros
Cons
Conclusion
Farnam produces a variety of highly-rated rodent-control products. Most of their products also utilize the ingredient bromadiolone, which kills rats and mice after just one feeding. These pellet packs are one of their more popular products, but they also make effective bait chunks in multiple different sizes.
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Our Rating: 4.8/5
Pros
Cons
Conclusion
This product comes with one bait station and 20 bait refills. Each bait refill can kill multiple mice or rats, so you likely won’t have to buy more refills than the ones already provided. Because this product already includes a bait station, it is much more resistant to tampering by children or pets. Additionally, this bait station can be placed indoors or outdoors and fits perfectly in corners, which mice often travel along.
Unlike the previous baits on this list, D-Con uses a non-anticoagulant rodenticide (cholecalciferol). There’s no antidote for this poison, so avoiding accidental ingestion by people or animals other than the targets is crucial. This bait should kill rodents with one single feeding, but it may take one to two weeks to exact its lethal effects.

Our Rating: 4.5/5
Pros
Cons
Conclusion
Tomcat’s Bait Chunx Pail uses a different active ingredient than the other baits on this list. Specifically, Tomcat makes this bait with bromethalin, a single dose non-anticoagulant. So, it uses a different method to kill rodents than the other baits, but it’s just as effective. This particular product comes with 4 lbs of bait and may be especially useful if rodents bothering you seem to be anticoagulant resistant, making it one of the best poison for killing rats and mice.

Conclusion
We’ve rated the JT Eaton Bait Block Rodenticide the highest because we think it will be the most useful for the largest number of consumers. This rodenticide prevents bait “shyness” (aka keeps rodents coming back for multiple feedings), has a low likelihood of secondary poisoning, and has a 1-year limited warranty. The JT Eaton Bait Block also possesses many similarities to the rodenticides offered in the Contrac All-Weather Blox or the Farnam Just One Bite Pellet Packs. If these three rodenticides have failed to get rid of your rodent problems, your rodents may be resistant to the anticoagulant poison they use. Instead, you can opt for the D-Con Corner Fit Mouse Poison Bait Station or the Tomcat Bait Chunx Pail to solve that issue. All of the rodenticides featured on this list use effective, reliable ingredients and are the best rat and mouse poison currently on the market.
Never use rat and mouse poison around pets or children. Be sure to follow all safety precautions included on the product labels to make sure you kill all the rats and mice bothering you but no other animals in the process!